Born in 1975 in Lviv.
Has higher education. In 1997 he graduated from Lviv Polytechnic National University with a degree in production management (mechanic engineering), engineer-economist. Ph.D. in Economics (2003).
From 1995 to 2009 Denys Shmyhal served in leadership positions at enterprises in Lviv.
From 2009 to 2013 he worked in Lviv Regional State Administration.
In 2014 Denys Shmyhal was appointed deputy Head of the Main Department of the Ministry of Revenue and Duties in Lviv region.
2015-2017 - Advisor‚Vice President‚ CEO, Member of the Supervisory Board of Lvivholod Ltd.
2017-2019 - deputy Director General for social issues of PJSC DTEK Zakhidenergo, Director of DTEK Burshtyn TPP, acting deputy Director General for social issues, PJSC DTEK Zakhidenergo; Burshtyn, Ivano-Frankivsk region.
From August 2019 to February 2020 – head of Ivano-Frankivsk Regional State Administration.
On 4 February 2020, Denys Shmyhal was appointed Deputy Prime Minister of Ukraine, Minister of Communities and Territories Development of Ukraine.